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KMID : 0043320120350101757
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Archives of Pharmacal Research
2012 Volume.35 No. 10 p.1757 ~ p.1762
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Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640
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Zhuravleva Olesya I.
Afiyatullov Shamil Sh.
Vishchuk Olesya S.
Denisenko Vladimir A.
Slinkina Natalya N.
Smetanina Olga F.
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Abstract
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A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma cells with IC50 values of 0.9 μM.
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KEYWORD
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Aspergillus sulphureus, Decumbenones, Cytotoxic activity
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